Deep Dive MW R22

Guillain-Barre Syndrome (GBS) – Autoimmune polyneuropathy that results in widespread demylination of peripheral nerves Typically occur 1 week after a triggering infection Paresthesias/Neuropathic Pain -> Ascending symmetric paralysis -> Respiratory Failure Major Diagnostic Criteria * Progressive limb weakness in multiple limbs that is relatively symmetric * Diminished/Absent deep tendon reflexes in affected limbs * No alternative diagnosis * CSF studies have false-negatives – May see albuminocytologic dissociation (Elevated protein with normal cell counts) Treatment – IVIG and monitor respiratory status