tPA (Deep Dive R29)

EM Clerkship - A podcast by Zack Olson, MD and Michael Estephan, MD

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Education

tPA usage is controversial. Listen to find out why. Read more to form your own opinions. Episode Sources: After Re-Analysis, No Trials Show Efficacy of tPA in Acute Ischemic Stroke Clinical Policy: Use of Intravenous Tissue Plasminogen Activator for the Management of Acute Ischemic Stroke in the Emergency Department Why we can’t trust clinical guidelines – BMJ Alteplase for Stroke: Money and Optimistic Claims Buttress the “Brain Attack” Campaign Tissue Plasminogen Activator (tPA) for Acute Ischemic Stroke: Net benefits and harms unclear due to uncertainty in data – the NNT